Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii), Ni (ii) and Co (ii) complexes

Authors

  • Haftom Welderufael Organic chemistry, Department of Chemistry, Hawassa University, Hawassa, Ethiopia
  • Dagne Addisu Kure Department of Chemistry, Hawassa University, Hawassa, Ethiopia
  • Endalkachew Asefa Moges Department of Chemistry, Hawassa University, Hawassa, Ethiopia
  • Lelishe File Department of Chemistry, Hawassa University, Hawassa, Ethiopia
  • Salah Hamza Sherif Department of Chemistry, Hawassa University, Hawassa, Ethiopia

Abstract

Benzimidazole is one of the privileged nitrogen-containing heterocyclic compounds, which is found in many bioactive compounds, benzimidazole and its derivatives have evolved as an important heterocyclic system due to their potency in a wide range of biologically active compounds like anthelmintic, antibacterial, antifungals, anti-inflammatory, antiviral, and so on. Derivatives of 1-arylsulfonylbenzimidazole and their respective Cu (II), Ni (II) and Co (II) complexes were successfully synthesized. The structures of all the synthesized ligands were confirmed by using IR, UV-Visible, 1H NMR, and 13C NMR spectroscopy. The Cu (II), Ni (II) and Co (II) complexes were confirmed by using IR and VU-Visible spectra.  The IR spectra of ligands and its metal complexes imply that the benzimidazol derivative ligands behave as basic bidentate ligands coordination through the azomethine nitrogen and oxygen atom. In-vitro antibacterial activity of all the synthesized ligands and their metal complexes were evaluated by using disc diffusion method against K. pneumoniae, E. coli, and S. aureus bacterial species .The tested compounds and metal complexes exhibited from good to excellent activity (zone of inhibition (ZI) ranged 10 mm to 23 mm). Compound BIL1 exhibited better activity than the standard drug against E. coli (ZI of 15 mm) and K. pneumoniae (ZI of 5 mm)compared with gentamycin ((ZI of 15mm). Complex CoC exhibited better activity against S. aureus (ZI of 23 mm) compared with gentamicine  (ZI value of 21 mm). This compound is a good starting point to develop new drug for treating pathogenic diseases. Therefore, synthesis of more analogue were recommended for further discovery of a new drug candidate.

Author Biographies

Endalkachew Asefa Moges, Department of Chemistry, Hawassa University, Hawassa, Ethiopia

chemistry, MSc

Lelishe File, Department of Chemistry, Hawassa University, Hawassa, Ethiopia

chemistry, MSc

Salah Hamza Sherif, Department of Chemistry, Hawassa University, Hawassa, Ethiopia

chemistry, Assistant professor

Additional Files

Published

2023-04-05

How to Cite

Welderufael, H., Kure, D. A., Moges, E. A., File, L., & Sherif, S. H. (2023). Synthesis, Characterization and Antibacterial activity of Benzimidazole Derivatives and their Cu (ii), Ni (ii) and Co (ii) complexes. East African Journal of Biophysical and Computational Sciences, 4(1), 42-51. Retrieved from https://journals.hu.edu.et/hu-journals/index.php/eajbcs/article/view/671